The UK’s King Charles has been diagnosed with cancer, though reportedly at an early stage. This follows a brief hospital stay where he underwent a procedure for a benign enlarged prostate. For the time being, he will not being public duties, but will continue his private duties.
Speaking to the BBC, UK Prime Minister Rishi Sunak said that the cancer was “caught early”. The nature of the cancer was not disclosed by Buckingham Palace, which is in line with its usual practice of sharing only basic information concerning the health of the royal family. It however noted that it was not connected to his prostate treatment, ruling out prostate cancer.
Well-wishes for the king have come in from around the globe. Mia Mottley, Barbados’ first female PM, wished wishes King Charles a “full and speedy recovery”. Barbados became a republic in 2021, ending the the role of UK monarchs as its Head of State.
Since the UK is a constitutional democracy, his private duties consist of governmental approvals. For example, the king has constitutional duties, such as approving the passing of laws and appoints new judges, ambassadors and prime ministers. Public activities such as charity events and giving honours for public or voluntary service.
It is expected that certain activities such as his weekly meetings with Prime Minister Sunak will continue unless his doctors advise otherwise. Other members of the royal family will be able to stand in for him for ceremonial duties if he is unable to perform them. Recently, 41-year-old Catherine, Princess of Wales,
It is not an unexpected medical condition to occur for the 75-year old monarch – age is a major factor for almost all cancers – just over a quarter of all cancers are diagnosed from age 75 onward. The American Cancer Society now recommends general cancer screenings start at 45.
New Year’s Day saw the Gauteng Department of Health welcoming 112 babies into the world, the lion’s share of more than 400 births in total for the country. According to data released by Gauteng Health on X/Twitter, in the province’s public healthcare facilities, there were a total of 59 boys and 53 girls. Thelle Mogoerane Regional Hospital topped the table with 10 babies, followed by Chris Hani Baragwanath Academic Hospital (CHBAH) with 9 babies. But all of this was relatively quiet compared to Christmas Day, which saw more than three times the New Years’ Day number.
MEC Nkomo Nomantu together with MMC for Health Rina Marx joined the postpartum mothers at Dr George Mukhari Academic Hospital on the morning of New Year’s Day in welcoming their new arrivals. Gauteng’s academic hospitals recorded 19 births, while there were 10 births at the tertiary hospitals. Regional and district hospitals had 69 births and community healthcare centres had 14.
Christmas Day saw 387 babies born, 201 of them girls and 186 boys. CHBAH welcomed the most, with 46 births, followed by Tembisa Hospital with 38.
Universal Health Coverage Day calls on us to reflect on the progress that we have achieved in providing healthcare for all. As the health and pharmaceutical industries, it is time to question if our strides in achieving healthcare for all are successful and identify areas for improvement. The theme “A Time for Action”, speaks to the urgency of healthcare access regardless of socioeconomic status, age, race or demographic. It is not an ambitious dream and can be attained in our lifetime, writes Bada Pharasi, CEO of the Innovative Pharmaceutical Association of South Africa (IPASA).
Universal Health Coverage (UHC) means access to primary healthcare for everyone. In South Africa, this is referred to as National Health Insurance (NHI). Regardless of its name, the objective remains the same – to ensure that all citizens, regardless of where they live or their socioeconomic status, have access to healthcare.
A 2021 report released at the Africa Health Agenda International Conference (AHAIC) revealed that 615 million, or 52%, of the people in Africa, did not have access to the healthcare that they needed¹. It was also estimated that 97 million Africans face catastrophic healthcare costs, which push 15 million people into poverty every year¹.
The effective implementation of UHC would mean that no person would have to go without appropriate healthcare. It would also mean that no person would have to undergo financial strain to receive treatment for ill health.
UHC covers a spectrum of health needs from health promotion to prevention, treatment, rehabilitation, and palliative care across the life course². In 2015, 193 United Nations (UN) member states agreed on the 2030 Sustainable Development Goals (SDG). These goals are aimed at seeing an end to poverty and a sustainable future by 2030², and ensuring health coverage for all is an integral part of reaching these goals.
The World Health Organization (WHO) believes that UHC can be achieved by using the primary healthcare approach as it remains the most accessible, inclusive and cost-effective method to reach the majority of the population².
Globally, as many as 72 countries have included UHC in their national healthcare systems. The countries where UHC has been the most successful include Canada, Australia, and several European countries, such as Switzerland and Sweden. It is from these countries that we can glean valuable lessons on the importance of strong healthcare systems, well-trained healthcare professionals and a cohesive relationship between governments and the private sector³.
Ensuring a healthier nation may seem like an exorbitant mission. However, when we consider that a healthier population will be beneficial to the economy, it makes for a worthwhile investment. The World Bank adds that UHC allows countries to make the most of their strongest asset: human capital. A nation in good health is one where children can go to school and adults can go to work⁴.
There is a common perspective that for a country’s overall health to improve, its economy must improve first. This idea fuels the understanding of why low- to middle-income countries have such poor healthcare infrastructure. The World Bank offers an alternative perspective, suggesting that when a country’s overall health improves, so will its economy. This as more citizens will be able to contribute to its economic growth and the workplace⁵.
Some of the reasons why the adoption of UHC in African countries has seemed to stall include inadequate financial and technology support, limited pharma manufacturing companies, and unclear policies and regulatory frameworks⁶.
In South Africa, the greatest hindrance to people receiving the healthcare they require boils down to numbers. With a population of more than 60 million people, there is a greater need for healthcare than there is capacity to meet the demand⁷.
At IPASA, we believe that healthcare is a basic right and that citizens in any given country should be given the necessary access to healthcare. We understand that working with key stakeholders, such as the government, is critical to the success of universal healthcare. Our ongoing work with patient advocacy groups ensures we understand what patients need from a treatment perspective.
We recently attended the Access Dialogue conference with patient advocacy groups including Rare Diseases South Africa and Campaigning for Cancer to gain an understanding of some of the concerns faced by patients and share insights on the proposed NHI Bill.
IPASA believes that an adequate supply of medicines is a critical pillar of any healthcare scheme, and the NHI is no different. For the NHI to succeed, it must be backed by a sustainable healthcare sector to ensure the security of healthcare provision and medicine supply.
To this end, the NHI must allow for a flexible, responsive pricing model that includes alternative/innovative reimbursement models to cover the cost of medicines and health products. This allows responsiveness to the needs of geographical areas, quality and levels of care, and negotiations directly with healthcare providers.
Healthcare for all can only be achieved by the joint commitment of the health and pharmaceutical industries, government stakeholders and patient advocacy groups for the benefit of patients. No person should be faced with the obstacle of finance at a time when they need healthcare: providing healthcare for all results in a healthier society and healthier world for us all.
Dr Vuyiseka Dubula-Majola, the former General Secretary of the Treatment Action Campaign, reflects on her journey and new role at the Global Fund. PHOTO: Joyrene Kramer
By Biénne Huisman for Spotlight
Dressed in a dark jacket, rain is pelting Vuyiseka Dubula-Majola’s face as she rushes past bare trees in Geneva, Switzerland. Along with her two children, Dubula-Majola has newly moved into a house in nearby Genthod, from where she commutes to work by train.
In October, the Global Fund to Fight AIDS, Tuberculosis [TB] and Malaria, appointed Dubula-Majola as head of their community, rights and gender department. The Global Fund has allocated tens of billions of dollars around the world to fight HIV since its inception in 2002.
Five weeks into the job, Dubula-Majola tells Spotlight that a big challenge for her will be to hone a new tool – that of diplomacy.
Laughing, the former General Secretary of the Treatment Action Campaign (TAC) says that in the past, diplomacy has not been her greatest strength.
“In this new job, I am required to be diplomatic,” she says. “Basically, diplomacy is being nice in the face of atrocities, and I am not that person. So it will be a huge challenge for me, it’s going to take a shift. I will have to keep asking myself, ‘what value I can add in this position?’ While developing new tools and new ways of fighting, without being the noisy person in the room.”
The power of collective action
Known for not mincing her words, the activist-scholar is talking to Spotlight over Zoom while walking to the Global Fund’s offices in central Geneva. She adds: “Activists don’t like bureaucracies by nature, but you have a voice here. You have political currency to shift things. It’s a tough one, but I’m there.”
In a 2014 TedX talk hosted in London, an inflamed Dubula-Majola told the audience that she is angry – angry with her father, angry with her government, angry at everyone. But that she was using her anger to fuel her work.
Vuyiseka Dubula-Majola was recently appointed at head of the Global Fund’s community, rights and gender department. PHOTO: Supplied
While she is in Switzerland, Dubula-Majola’s heart still brims with African proverbs, such as: “When spider webs unite, they can tie up a lion.” She has experienced the power of such collective action first-hand at the TAC, but now she’ll be applying it on a different stage. Indeed, her new job is “to ensure that the Global Fund strongly engages civil society and promotes human rights and gender equality”, with a particular focus on supporting community led organisations.
As a role model for her new diplomatic duties, Dubula-Majola cites American public health official Loyce Pace. “Loyce Pace who runs the health program in the United States government, she is very effective in what she does while hardly saying anything in public. But she is shifting norms – bringing priority to black and poor people. She uses her allies and many other people similar to her to say things louder than she could…I guess this is another step of growth in my activist journey – to still be as effective, as radical, the very same eagerness and passion, but silently.”
‘There was no time to dream’
Dubla-Majola grew up in a village near Dutywa in the Eastern Cape. Aged 22 in Cape Town in 2001, she spiralled with depression after being diagnosed with HIV. But instead of resigning herself to what was then still a death sentence for most people, she joined the TAC – working night shifts at the McDonalds drive-through in Green Point, while by day she joined the fight to bring antiretrovirals and other medicines to South Africa.
“As a 22-year-old, I did not have fun, there was no time to dream,” she recalls. “I was fighting for my life and the lives of others. I never thought I would have children, I never thought I would get married, I never thought I would love again. Because there was also the issue of who infected me, how did this happen? You start resenting relationships.”
At the forefront of social justice activism for most of South Africa’s young democracy – a role model for people living with HIV, and for those fighting inequality – Dubula-Majola lead the TAC from 2007 to 2013, after which she joined Sonke Gender Justice as director of policy and accountability. She holds an MA in HIV/AIDS management from Stellenbosch University; her PhD from the University of KwaZulu-Natal examined “grassroots policy participation after a movement has succeeded to push for policy change,” using MSF’s [Médecins Sans Frontières] pioneering antiretroviral sites in Khayelitsha and Lusikisiki as samples.
‘Build and regain the dignity of poor people’
In 2018, when Stellenbosch University offered her a job as director of its Africa Centre for HIV/AIDS Management, Dubula-Majola was circumspect. Why take up appointment at a white male-dominated institution shackled by slow transformation, in an elitist town? But she took on the challenge to become the transformation she wanted to see.
Dubula-Majola tells Spotlight that while relishing the privilege of academia – a space to reflect – it saw her away from “the heat of the activist fire” for too long. Five years later, a new challenge awaits.
Reflecting on Stellenbosch, she says: “This [job at the Global Fund] is even harder, because it’s not just one country, one university. This is all the continents of the world. All of them facing the same thing, the struggle here is to build and regain the dignity of poor people around the globe.”
Despite her early misgivings about relationships, Dubula-Majola married fellow TAC activist, Mandla Majola. Their children, now aged 10 and 16, are HIV-negative. Presently Majola is helping with their friend Zackie Achmat’s independent campaign for the 2024 general elections, after which he will join his wife in Geneva. The family will unite in Switzerland for Christmas though – “which will be the most miserable and cold Christmas,” says Dubula-Majola, laughing. “It will be our first winter Christmas and our last. As we just arrived a month ago, it doesn’t make sense to travel back to South Africa for the holidays.”
Overall she says she remains hopeful, adding that movements like #MeTo are lessons in global solidarity.
Her thoughts on continuing the fight against HIV: “It is up to HIV positive people, and those who want to remain HIV negative, to steer towards an AIDS-free generation. We must stop complaining, thinking politicians will do everything for us, and do it ourselves.”
Meanwhile, Global Fund representatives have voiced confidence in Dubula-Majola’s ability to lead. Marijke Wijnroks, head of the organisation’s strategic investment and impact division, said in a statement: “Following an extensive search process, I am delighted to say that we found the ideal person for this role. As a person living with HIV, Vuyiseka’s lived experience and leadership style are well aligned to what we need from this critical role.”
Note: Dubula-Majola is a former General Secretary of the TAC. Spotlight is published by SECTION27 and the TAC, but is editorially independent – an independence that the editors guard jealously. Spotlight is a member of the South African Press Council.
Renowned clinician, researcher and educator Professor Harry Seftel has passed away at the age of 94. For many, he was well-known for his radio appearances concerning health and medicine. Hailed as a “national treasure” by President Cyril Ramaphoa, Prof Seftel contributed greatly to the study of non-communicable diseases in South African populations and was a strident critic of apartheid.
The Wits Faculty of Health Science posted on Twitter/X: “The Faculty mourns the passing of Professor Harry Seftel, distinguished professor of medicine at @WitsUniversity. Renowned for making complex medical issues accessible to all, Prof. Seftel was a passionate advocate for health promotion.”
Born on 28 December 1928, Harold Cecil Seftel became an intern at Baragwanath Hospital in 1953 shortly after receiving his medical degree, and by 1982 was Professor of Medicine and Chief Physician at Hillbrow Hospital.
An outstanding clinician, he contributed greatly to the categorisation of infectious and non-infectious diseases among Black South Africans. He held numerous positions and received an honourary law degree from Wits.
His research interests focussed on diseases with a high prevalence in various South African populations: oral iron overload, cryptogenic cardiomyopathy and arterial hypertension among Black Africans; coronary artery disease and diabetes mellitus among Asians and familial hypercholesterolaemia among Afrikaaners.
He encouraged research at many levels, authoring more than 200 publications in fields ranging from endocrinology to infective diseases. In doing so, he collaborated with many of the finest minds in their fields, locally and internationally.
Not content with confining his teaching to academia, he also educated the general public with presentations in the media, becoming a familiar face over the years. He became known for many catchphrases, with “trust no one, least of all yourself” being one of his most revealing.
Prof Seftel was also friends with Nelson Mandela, having met him at Wits University. While Nelson Mandela was in prison, he heard one of Prof Seftel’s broadcasts and reduced his salt intake to help with the health problems he suffered throughout his incarceration. Not surprisingly, Prof Seftel was a strident critic of apartheid and the gross inequalities it produced.
In his 1973 inaugural lecture at Wits, he said of the distribution of medical service South Africa: “The present situation is deplorable and shameful. The man from Mars who is due here shortly would find it quite incomprehensible. In particular he would find our system of priorities wholly illogical and immoral.”
The United Nations International Volunteer Day, celebrated annually on 5 December, is a unique opportunity for volunteers and organisations worldwide to celebrate their contributions, share their values, and promote their work within their communities. The theme for 2023 is: “The Power of Collective Action: If Everyone Did.”
The United Nation’s (UN) fourth State of the World’s Volunteerism Report (SWVR 2022), titled Building Equal and Inclusive Societies, shows that the ways in which volunteers and entities interact, collaborate and partner are vital for the achievement of the 2030 Agenda for Sustainable Development and the Sustainable Development Goals.
Volunteerism plays a crucial role in promoting a culture of collaborative decision-making and reshaping power dynamics. Volunteers can act as connectors, bridging the gap between different groups and facilitating better understanding and cooperation.
“At Sanofi South Africa, we understand the immense value of collective efforts in building a healthier, more resilient world for patients, communities, partners, and employees,” says Prudence Selani, Head of Corporate Affairs at Sanofi South Africa. “Our dedication to addressing some of the world’s most pressing challenges is evident in our comprehensive social impact strategy, which is now an integral part of our business, influencing every level of our organisation.”
Sanofi’s ‘Play to Win’ strategy, intensifies the pharmaceutical company’s focus on improving healthcare access, reducing its environmental footprint, and building an inclusive workplace. This commitment extends to ensuring a sustainable planet for future generations.
The organisation is making a lasting impact through its corporate social responsibility (CSR) legacy project in Mamelodi, in the City of Tshwane, which forms part of Sanofi’s global In and Beyond the Workplace social impact strategy pillar – “to reflect the diversity of its communities, unleash the full potential of its employees, and transform healthcare to be more inclusive and equitable.”
After engagement with numerous organisations, Sanofi partnered with Entokozweni Resource Centre in Mamelodi to make a real difference in people’s lives. The non-profit organisation is dedicated to uplifting the Mamelodi community through a variety of programs and initiatives, focusing on long-term developmental goals and immediate community needs.
“The launch of our Legacy Project on 15 September 2023, at Entokozweni was a resounding success, drawing extensive support from our staff,” says Selani. “We dedicated the day to connecting with the people of Entokozweni and the broader community, marking the beginning of a long-lasting relationship.”
Support for the community includes:
Donating essential items such as mattresses, toiletries, stationery, uniforms, and clothing.
Providing 250 Coursera licences to empower Mamelodi’s youth with skills for employment and helping to transform the lives of their families and community.
Hosting the Mamelodi Community Health Centre’s (CHC) Purpose Day at Entokozweni, focusing on educating the community about gut health and the importance of hygiene.
Converting an illegal dumping site into a vibrant indigenous garden during the Sanofi Legal Ethics & Business Integrity department (LEBI) Giving Week, through collaborating with employees, local communities, and various stakeholders.
“As we celebrate International Volunteer Day, we are reminded of the importance of working together to effect real change,” says Selani. “Volunteerism is one of the most vital delivery mechanisms for social, environmental and economic transformation, ensuring a lasting impact because it can change people’s mindsets, attitudes, and behaviours. The power of collective action is not just a theme for a day but a guiding principle in transforming lives through united efforts.”
Join the UN in recognising volunteers all over the world using the hashtags #IfEveryoneDid and #IVD2023. SanofiVolunteers #InternationalVolunteerDay2023 #CollectiveAction #SocialImpact
The United Nations International Day of Persons with Disabilities (IDPD) is celebrated annually on 3 December, aiming to promote an understanding of disability issues and to mobilise support for the dignity, rights and well-being of persons with disabilities. An estimated 1.3 billion people experience significant disability.1a This represents 16% of the world’s population, or 1 in 6 of us.1a In South Africa, that figure is 15%, or 8,9 million.2a
Persons with disabilities face many health inequities, including stigma, discrimination, poverty, and exclusion from education and employment. They also face barriers in all aspects of the health system, such as negative attitudes and discriminatory practices and lack of information or data collection and analysis on disability.1b+c
“Disability inclusion is critical to achieving the Sustainable Development Goals (SDGs) and global health priorities to achieve health for all, as envisioned in the 2030 Agenda for Sustainable Development,” says Prudence Selani, Head of Corporate Affairs at Sanofi South Africa. On this International Day of Persons with Disabilities, Sanofi is celebrating its commitment to the 2023 theme, ‘United in Action to Rescue and Achieve the Sustainable Development Goals (SDGs) For, With, and By Persons with Disabilities,’ through several initiatives.
In collaboration with its implementation partners, Sanofi has launched a unique external training programme for persons with disabilities, especially those from disadvantaged communities. This programme is designed to break barriers to education post-matriculation, offering management training and entrepreneurship skills in areas like financial literacy and marketing. This initiative also supports people with post-matric qualifications striving for employment, enhancing their employability and professional growth.
“As part of our commitment to Broad-Based Black Economic Empowerment (B-BBEE), 10% of learners on our Youth Employment Service “Y.E.S.” programme are persons with disabilities, underlining our commitment to diversity and inclusion,” says Selani.
Sanofi’s Diversity, Equity and Inclusion is bolstered through Employee Resource Groups (ERGs). The Ability+ ERG promotes a safe environment for employees to declare their disabilities, offering support and resources. Sanofi is also offering employees the chance to enrol in South African Sign Language courses, to transform its workplace into a disability-friendly space.
“Our partnerships with local and global organisations that are focused on disabilities will enable us to conduct workshops with leaders and employees, fostering a culture of understanding and empathy.”
“Sanofi also emphasises employee wellness and mental health, offering extensive support and wellness programmes,” says Selani. “These initiatives underscore our dedication to the well-being of all our employees.”
“As we mark IDPD 2023, Sanofi encourages organisations across all sectors to join us in these efforts. Together, we can make significant strides towards a more inclusive society and achieving the SDGs for, with, and by persons with disabilities,” concludes Selani.
Together, we are making a difference. Join us in our journey towards an inclusive future.
A “gentle and loving” person who “paid the ultimate sacrifice” for making sure those who needed it received aid. This was how Ahmed Abbasi, who headed the Gift of the Givers office in Gaza, was remembered at an interfaith memorial service in St George’s Cathedral, Cape Town, on Sunday evening.
At least 400 people came to pay their respects. Several faith leaders were in attendance as well as government officials, including Cape Town Mayor Geordin Hill-Lewis and former international relations minister Lindiwe Sisulu.
Gift of the Givers’ Western Cape project coordinator Ali Sablay told GroundUp that Abbasi and his brother, Mustafa, were killed by a missile while returning from their morning prayer.
Abbasi leaves behind his wife and three children. They have been relocated to a place of safety.
Sablay said that Abbasi was responsible for setting up a women and children care centre, three desalination plants, supplying medicines to hospitals, and more.
“He was the head of this operation and in the last 40 days of this war, he’s been remarkable in the work he’s been doing in getting aid to those affected. He had the option to relocate but he said he could not leave the people behind. He stayed on with his family. Unfortunately, he paid the ultimate price.”
Sablay said the organisation backed President Cyril Ramaphosa’s decision to refer members of the Israeli government to the International Criminal Court (ICC). “We support the political parties that are asking that the Israeli ambassador be expelled. This is not an act of war, this is an act of genocide,” he said.
Reverend Michael Weeder, dean of the cathedral, led the service. Reverend Allan Boesak gave the sermon.
Megan Choritz read out a letter of condolence on behalf of South African Jews for a Free Palestine. “There has never been a moment of crisis where Gift of the Givers has not stepped up and offered help, solace, dignity and hope to those affected. Please, in this dark moment for you and your organisation, accept our prayers, solidarity and support.”
“We will continue to speak up, continue to disavow any claims that this war is waged in our names, or in the name of Judaism,” she said.
The service was interspersed with hymns, songs and poetry readings. Several faith leaders addressed the congregation.
In a pre-recorded message, Dr Imtiaz Sooliman, founder of Gift of the Givers, thanked Father Weeder for organising a memorial service for someone he had never met. “This is not a head of state, a minister, or a person of high rank. He’s just an ordinary Palestinian, but he works for Gift of the Givers and that makes him special, even if I say so myself.”
In an interview with GroundUp last month, Sooliman described Gaza as “the worst situation in the world because there is no exit route”.
“You can’t get out. The area is so small. It’s so easy to bomb it … Nobody can have a safety plan. Where are you going to hide? There’s no such thing as safety in Gaza,” he said.
The New York Times reported last week that over 100 aid workers in Gaza have been killed in the past five weeks.
I hope this newsletter finds you in good health and high spirits. As part of Doctors’ Day on 16 November, my team and I wanted to take a moment to express our deepest gratitude and appreciation for the incredible work you do every day.
On this special occasion, we celebrate you and your fellow doctors for the remarkable impact you make on the lives of those you serve. Your expertise, resilience, and compassionate care contribute to the betterment of our community and the well-being of countless individuals. We recognise the challenges you face, especially in these unprecedented times, and we are inspired by your continued efforts to provide exceptional healthcare.
At EthiQal, we take pride in supporting doctors like you. We are committed to ensuring that you have the comprehensive insurance coverage you need, allowing you to focus on what matters most – your patients.
To mark this occasion, we extend our warmest wishes for a Happy Doctors’ Day! May you find time to reflect on your accomplishments and the positive impact you’ve made on the lives you’ve touched.
As a token of our appreciation, we have created a small thank you video. Please click on the video below – it may be a small gesture, but we hope it brings a smile to your face and serves as a reminder of the impact you make every day.
We are also donating, on your behalf, to the Healthcare Workers Care Network (HWCN), a nationwide healthcare worker mental health support network with the slogan ‘Caring for the Carers by Carers’. They do great work supporting doctors, sustained only by financial donations and pro bono work.
Thank you for your tireless dedication, and we look forward to continuing to support you whilst you focus on making our nation healthier.
Members of the University of Cape Town’s Holistic Drug Discovery and Development Centre H3D
A formidable disease that has plagued humanity for centuries, malaria has exacted a heavy toll on human lives, disrupting communities and hindering socio-economic progress across some of the most vulnerable regions of the world, particularly the African continent.
With its stealthy transmission through the bites of infected mosquitoes, malaria has earned the dubious reputation of being one of the deadliest vector-borne diseases on the planet. So much so that the World Health Organization’s World Malaria Report reveals that malaria cases are on the rise, with instances rising from 245 million cases in 2020 to over 247 million a year later1.
With an estimated 619,000 people succumbing to the disease in 20211, it remains a defining challenge for global healthcare systems. However, through the unyielding persistence and spirit of medical innovation and scientific ingenuity exemplified by research facilities such as the University of Cape Town’s Holistic Drug Discovery and Development Centre (H3D), solutions to mitigate the severity of malaria are on the horizon.
“As the first and only integrated drug discovery platform on the African continent, H3D’s mission is to discover and develop innovative life-saving medicines for diseases that predominantly affect African patients,” explains Bada Pharasi, CEO of the Innovative Pharmaceutical Association of South Africa (IPASA).
H3D’s focus on building Africa-specific models aims to improve treatment outcomes in African patients and to educate and train a critical mass of skilled African-based drug discovery scientists. H3D’s scientific output and research model includes attracting international investment in local innovative pharmaceutical research and development (R&D) across the African continent to address the disproportionately high global disease burden. Importantly, H3D targets critical infectious diseases, including tuberculosis, antibiotic-resistant microbial diseases, and malaria.
“Given the vulnerability of many of the African populations, the continent accounted for 95% of malaria cases and 96% of malaria deaths in 20211. Accordingly, continued antimalarial drug research and development, such as the studies conducted by H3D, is important to prevent and treat the millions of cases that arise each year, all of which have consequences on both the health and socioeconomic development of the continent,” adds Pharasi.
Since the official launch of H3D’s programs in April 2011, there have been notable advances in innovative drug discovery projects. The centre has demonstrated a strong track record with multiple chemical series discovered and being progressed at H3D in each stage of the drug development pipeline.
A significant achievement reached by H3D was the discovery of the malaria clinical candidate, MMV390048, which reached phase II human trials in African patients. This was the first ever small molecule clinical candidate, for any disease, researched on African soil by an African drug discovery research unit.
According to Dr Candice Soares de Melo, Chief Investigator at H3D, the centre’s current anti-malarial programmes will focus on the identification of quality leads suitable for optimisation and candidate selection as potential agents for the treatment of uncomplicated Plasmodium falciparum malaria, ideally with additional activity against liver-stage parasites to offer protection and prevent relapses (in case of malaria caused by the species Plasmodium vivax), as well as blocking the transmission of the disease.
“A critical component of the research conducted at H3D is to develop medicines that are safe and sufficiently tolerated to be given to the widest range of recipients, including infants and pregnant women,” says Soares de Melo.
Besides the potential benefits of providing a new cure for malaria, H3D serves as a catalyst for training scientists in infectious disease research and influencing the R&D environment in Africa. As part of its partnership with the South African Medical Research Council, H3D has worked to mentor and develop scientists at other African universities, including those at Historically Disadvantaged Institutions (HDIs) within South Africa.
Furthermore, apart from strengthening drug discovery innovation at UCT, the centre has also taken a lead role in partnership with the Bill & Melinda Gates Foundation in catalysing drug discovery across sub-Saharan Africa, with upwards of 16 university research groups working on malaria and tuberculosis drug discovery.
“An example of this is the Phase 1 clinical trial for the H3D clinical candidate MMV390048, which was carried out at the UCT Division of Clinical Pharmacology,” adds Soares de Melo.
Another is the MATRIX independent special project, which has the potential to transform local drug manufacturing across the continent. Funded by the United States Agency for International Development (USAID), the project aims to pilot cost-effective local manufacture of antiretroviral Active Pharmaceutical Ingredients using flow reactor technology.
“Should Africa intend on a path to self-sufficiency, it’s important to drive continued investment in health innovations developed for and by Africa.
“We support the research efforts of H3D, and strongly believe that now is the time to take a deliberate and systematic approach to develop new capabilities, transfer technologies, leverage partnerships and networks, and train scientists, all while delivering on drug discovery projects to help address the continent’s, and the world’s, greatest health challenges,” concludes Pharasi.
