Categories : General Interest HIVTags :

Girl Effect in the Youth Drive at VUT to Close the HIV Treatment Gap

On By ModernMedia
Image caption, left to right: Dr Lisa Mulenga, Country Director of Girl Effect and Gauteng MEC for Health, Ms. Nomantu Nkomo-Ralehoko, engaging with a student at VUT.

Johannesburg, 13 May25: Girl Effect South Africa, a non-profit organisation, joined the Department of Health, South African National Aids Council, Higher Health, and other partners at the ‘Close the Gap Higher Education’ event which took place on Friday, 9 May, at the Vaal University of Technology (VUT). The campaign aims to connect young people with essential health services, encourage HIV testing and treatment, and help close the country’s significant treatment gap.

With young people making up a large proportion of the estimated 5.7 million South Africans living with HIV but not on antiretroviral therapy (ART), the campaign focuses on improving access to youth-friendly healthcare on campuses and in communities. The VUT activation is part of a national strategy to achieve the UNAIDS 95-95-95 targets, which aims to ensure that 95% of people living with HIV know their status, 95% of those are on treatment, and 95% of those on treatment achieve viral suppression.

Girl Effect brings its experience in youth-centred communication, behaviour change, and media to help break down stigma and promote informed, confident decision-making among young people. Its focus is especially on adolescent girls and young women, who remain at higher risk of HIV infection and are often underserved by the health system.

Through its flagship programme, Jik’iZinto, Girl Effect connects young women with transformative health education and digital engagement, empowering them to make informed decisions about their health and wellbeing.

Over 1 687 students accessed HIV counselling, testing, ART initiation and contraceptive services at the event and 38 700 female and male condoms where distributed amongst the young people. The young people were educated on oral Pre-Exposure Prophylaxis (PrEP), a daily pill that significantly reduces the risk of contracting HIV. Young people were also encouraged to conduct screenings for STIs, TB, and chronic diseases. Additionally, students actively participated in youth dialogues and peer-to-peer health education.

“Too often, young people face barriers, whether social, structural or emotional, that prevent them from seeking the healthcare they need,” said Dr Lisa Mulenga, Country Director of Girl Effect South Africa. “At Girl Effect, we work to remove those barriers by creating platforms where young people can access accurate information, engage with relatable content, and feel supported in making decisions about their health.”

Dr Mulenga, a public health and health systems expert with over two decades of experience, leads Girl Effect’s national strategy and programme delivery. The organisation collaborates with government departments, civil society and local partners to strengthen health messaging and improve access to services for underserved groups.

Gauteng MEC for Health, Ms. Nomantu Nkomo-Ralehoko, engaged with stakeholders during the event, culminating in a pledge signing ceremony. This event demonstrated the health department’s commitment to collaborative efforts in addressing health challenges and promoting meaningful partnerships.

The ‘Close the Gap Higher Education ’ campaign aligns with the National Strategic Plan on HIV, TB and STIs (2023 – 2028), which calls for improved service integration, greater community outreach, and targeted youth interventions. In addition to healthcare services, the VUT activation featured student-led dialogues, physical wellness activities, live performances, and keynote addresses from key decision-makers.

The campaign is being delivered in partnership with Shout It Now, Soul City, LoveLife, Aids Healthcare Foundation, the South African Police Service (SAPS), and various youth organisations. The goal is not only to increase uptake of services but to change the way young people experience healthcare, making it accessible, welcoming, and relevant to their lives.

Categories : VaccinesTags :

Needle-free Influenza Vaccines with Broad Protection

On By ModernMedia
Photo by CDC on Unsplash

A research team led by the University of Hong Kong have achieved an award-winning breakthrough in developing broadly protective, live-attenuated influenza vaccines (LAIV). These innovative LAIV platforms offer the potential to develop universal influenza vaccines that induce a more robust immune response against various virus subtypes, including both human and avian strains. Since they induce mucosal immune responses, they can also be administered nasally.

Current seasonal influenza vaccines protect primarily against three selected strains and require annual updates. Their efficacy can significantly decline if the circulating viruses do not match the strains chosen each year for each hemisphere. Moreover, these vaccines fail to guard against human infections caused by animal influenza viruses, such as avian strains, which pose a potential global pandemic threat. The World Health Organization (WHO) has underscored the urgent need for a new generation of universal influenza vaccines.

The research team developed two innovative approaches to create next-generation LAIVs. The first strategy involved engineering a human influenza virus with then gene for α-Gal, which is already targeted by human antibodies. Vaccine-infected cells then express α-Gal on their surfaces and boost vaccine-induced immune responses, including antibody-mediated cytotoxicity, opsonisation and phagocytosis.

The research data showed that the vaccine is attenuated in mouse models. Vaccinated mice showed strong innate and adaptive immune responses, including antibody and T-cell responses. These immune responses conferred broad protection against various influenza A virus subtypes, including human H1N1 and H3N2, and avian H5N1 strains.

The second approach to developing next-generation LAIVs involved introducing hundreds of silent mutations to a human influenza virus, shifting its codon usage from that of a human influenza virus to that of an avian influenza virus-like pattern. This shift resulted in the attenuation of the virus in mammalian cells, making it safe for use as an LAIV.

Additionally, the mutant virus replicated perfectly in chicken eggs, which is crucial for current effective vaccine manufacturing processes. With this approach, the viral protein expression of the LAIV remained identical to the original wild-type virus, providing a robust immune response against the viruses. The research team successfully generated several attenuated viruses with different human influenza virus backbones, including H1N1 and H3N2.

The development of these two award-winning LAIVs represents a significant advancement in the quest for broadly protective and efficient influenza vaccines. This new generation of LAIVs can both protect humans from seasonal influenza viruses and address the threat posed by emerging viruses, like avian influenza viruses.

“The advantages of LAIVs lie in their intranasal administration, which has been shown to induce mucosal immune responses along the respiratory tract, providing additional protection against infection,” highlighted Professor Leo Poon Lit-man, Chair Professor of Public Health Virology and Head of the Division of Public Health Laboratory Sciences, School of Public Health, HKUMed. “This needle-free delivery method alleviates the fear of vaccination, particularly in young children, so it will help mitigate vaccine hesitancy.”

Source: The University of Hong Kong

Categories : Ethics and Law IT in HealthcareTags :

The Evolution of AI in Patient Consent is a Data-Driven Future

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Henry Adams, Country Manager, InterSystems South Africa

One area undergoing significant evolution in the healthcare industry is the process of obtaining patient consent. It is a topic that is highly controversial but absolutely necessary and one that must evolve if we are to bring patient care into the 21st century.

Traditionally, patient consent has involved detailed discussions between healthcare providers and patients, ensuring that individuals are fully informed before agreeing to medical procedures or participation in research. However, as artificial intelligence (AI) becomes more prevalent, the mechanisms and ethics surrounding patient consent are being re-examined.

The current state of patient consent

Informed consent is a cornerstone of ethical medical practice, granting patients autonomy over their healthcare decisions. This process typically requires clear communication about the nature of the procedure, potential risks and benefits, and any alternative options.

In the context of AI, particularly with the use of big data and machine learning algorithms, the consent process becomes more complex. Patients must understand not only how their data will be used but also the implications of AI-driven analyses, which may not be entirely transparent.

The rise of dynamic consent models

To address these complexities, the concept of dynamic consent has emerged. Dynamic consent utilises digital platforms to facilitate ongoing, interactive communication between patients and healthcare providers.

This approach allows patients to modify their consent preferences in real-time, reflecting changes in their health status or personal views. Such models aim to enhance patient engagement and trust, providing a more nuanced and flexible framework for consent in the digital age.

AI has the potential to revolutionise the consent process by personalising and simplifying information delivery. Intelligent systems can tailor consent documents to individual patients, highlighting the most pertinent information and using language that aligns with the patient’s comprehension level. In addition, AI-powered chatbots can engage in real-time dialogues, answering patient questions and clarifying uncertainties, enhancing understanding and facilitating informed decision-making.

Data privacy, ethical and security considerations

The integration of AI into patient consent processes necessitates an increased attention to data privacy and security. As AI systems require access to vast amounts of personal health data, robust additional safeguards must be in place to protect against unauthorized access and breaches. Ensuring that AI algorithms operate transparently and that patients are aware of how their data is being used is critical to maintaining trust in the healthcare system, and AI in particular.

While AI can augment the consent process, the ethical implications of its use must be carefully considered. The potential for AI to inadvertently introduce biases or operate without full transparency poses challenges to informed consent. Therefore, human oversight remains indispensable.

Healthcare professionals must work alongside AI systems, the “human in the loop”, to ensure that the technology serves as a tool to enhance, rather than replace, the human touch in patient interactions.

The next 5-10 years

Over the next decade, AI will become increasingly integrated into patient consent processes. Experts predict advancements in natural language processing and machine learning will lead to more sophisticated and user-friendly consent platforms. However, the centrality of human judgment in medical decision-making is unlikely to diminish. AI can provide valuable support, but the nuanced understanding and empathy of healthcare professionals will remain vital.

So, as we take all of this into account, the evolution of AI in patient consent processes offers promising avenues for enhancing patient autonomy and streamlining healthcare operations. By leveraging AI responsibly, healthcare institutions can create more personalised, efficient, and secure consent experiences.

Nonetheless, it is imperative to balance technological innovation with ethical considerations, ensuring that human judgment continues to play a pivotal role in medical decision-making. As we navigate this new world, a collaborative approach that integrates AI capabilities with human expertise will be essential in shaping the future of patient consent. And for healthcare in South Africa, this is going to have to start with education.

Categories : Cardiovascular Disease Obstetrics & GynaecologyTags :

Does Anaemia During Pregnancy Affect Newborns’ Risk of Heart Defects?

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Source: Pixabay CC0

New research published in BJOG: An International Journal of Obstetrics & Gynaecology found that mothers who are anaemic in early pregnancy face a higher likelihood of giving birth to a child with a heart defect.

The study assessed the health records of 2776 women with a child diagnosed with congenital heart disease who were matched to 13 880 women whose children did not have this condition.

Investigators found that 4.4% of children with congenital heart disease and 2.8% of children with normal heart function had anaemia. After adjusting for potential influencing factors, the odds of giving birth to a child with congenital heart disease was 47% higher among anaemic mothers.

“We already know that the risk of congenital heart disease can be raised by a variety of factors, but these results develop our understanding of anaemia specifically and take it from lab studies to the clinic. Knowing that early maternal anaemia is so damaging could be a gamechanger worldwide,” said corresponding author Duncan B. Sparrow, PhD, of the University of Oxford. “Because iron deficiency is the root cause of many cases of anaemia, widespread iron supplementation for women—both when trying for a baby and when pregnant—could help prevent congenital heart disease in many newborns before it has developed.”

Source: Wiley

Categories : Mental HealthTags :

Differences in Object Grasping may Offer Simpler Diagnosis for Autism

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Photo by Peter Burdon on Unsplash

Getting a timely diagnosis of autism spectrum disorder is a major challenge, but new research out of York University shows that how young adults, and potentially children, grasp objects could offer a simpler way to diagnose someone on the autism spectrum.

The team, part of an international collaboration, used machine learning to analyse naturalistic hand movements – specifically, finger motions during grasping – in autistic and non-autistic individuals. Surprisingly, none of the simpler measures, such as time to grasp (reported to be slower in autistic adults), proved to be a reliable predictor.

“Our models were able to classify autism with approximately 85 per cent accuracy, suggesting this approach could potentially offer simpler, scalable tools for diagnosis,” says lead author, Associate Professor Erez Freud of York’s Department of Psychology and the Centre for Vision Research.

“Autism currently affects about one in 50 Canadian children, and timely, accessible diagnosis remains a major challenge. Our findings add to the growing body of research suggesting that subtle motor patterns may provide valuable diagnostic signals – something not yet widely leveraged in clinical practice.”

In addition to social and communication challenges, autism, a neurodevelopmental disorder, can include motor abnormalities which often show up in early childhood. The researchers say testing for these motor movements early could lead to faster diagnoses and intervention.

“The main behaviours markers for diagnosis are focused on those with relatively late onset and the motor markers that can be captured very early in childhood may thus lower age of diagnosis,” says Professor Batsheva Hadad of the University of Haifa, an expert in autism research and a key collaborator in this study.

Autistic and non-autistic young adult participants were asked to use their thumbs and index fingers, which had tracking markers attached, to grasp different blocks of varying size, lift each one and replace it in the same spot, and put their hand back in the starting position. The researchers used machine learning to analyse the participants’ finger movements as they made grasping motions.

Both groups of participants had normal IQ and were matched on age and intelligence. Young adults were used instead of children to rule out any differences in the findings due to delayed development.

The research found that subtle motor control differences can be captured effectively with more than 84% accuracy. The study also showed there were distinct kinematic properties in the grasping movements between autistic and non-autistic participants.

Analysis of naturalistic precision grasping tasks has not typically been used in previous studies, says Freud. Machine learning, however, provides researchers with a powerful new tool to analyse motor patterns, opening new ways to use movement data in the assessment of autism spectrum disorder.

The findings, says Freud, could lead to the development of more accessible and reliable diagnostic tools as well as timely intervention and support that could improve outcomes for autistic individuals in the future.

The paper, Effective autism classification through grasping kinematics, was published in the journal Autism Research.

Source: York University

Categories : AntibioticsTags :

Discovery of Antibiotic Resistance in Newly Identified Bacterium

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Jorunn Pauline Cavanagh holds up a petri dish with the newly discovered bacterium.

In 2020, a research group at UiT The Arctic University of Norway in Tromsø discovered a previously unknown bacterium. Named Staphylococcus borealis (S. borealis) after the Northern Lights, the researchers investigated whether this newly discovered bacterium was a potential threat. Their findings were published in the journal Microbiology Spectrum.

33% Antibiotic Resistance

To investigate, researchers collected bacterial samples stored in freezers at several Norwegian hospitals.

The samples went as far back as 2014, and the researchers conducted new tests to see if they could identify the new bacterium in the old samples. Meanwhile, new samples arriving at the UiT lab from 2020 to 2024 were tested continuously. In total, the researchers collected and analysed 129 samples from seven Norwegian hospitals.

It turns out that S. borealis is resistant to more than three different classes of antibiotics in one-third of the cases where it was tested. 

Moreover, the bacterium also appears to be highly adept at acquiring protective mechanisms from other bacterial species. This means it could potentially develop antibiotic resistance quickly, when attacked with the medicines currently available.

“We see the most resistance against the antibiotic classes fusidic acid, cephalosporins, penicillins, macrolides, and fluoroquinolones,” explains Jorunn Pauline Cavanagh, who led the work on bacterial analyses.

A Problem for the Elderly

S. borealis is a bacterium that lives on our skin, and researchers have found that it can become problematic when your immune system is weakened. This makes it particularly concerning for the elderly and for those who have had knee or hip replacements. 

“This bacterium is an opportunist that can cause illness when your immune system is compromised. For example, we see that it can form what’s called biofilm around knee prostheses and cause infections that can be difficult to treat,” explains Jorunn Pauline Cavanagh. 

Researchers are now working to determine which diseases this bacterium can cause. Preliminary findings suggest it may lead to urinary tract infections, as well as inflammation in areas where implants are present.

“We do know that it causes mastitis in dromedary camels. This is because we’ve published the bacterium’s genetic profile in international databases, which other researchers use to compare their own bacterial findings. So, more possibilities may emerge,” says Cavanagh.

Source: UiT The Arctic University of Norway

Categories : Diet and NutritionTags :

Intermittent Fasting: Is it the Calories or Carbs that Count?

On By ModernMedia
Photo by Ayako S

Adam Collins, University of Surrey

Intermittent fasting is not only a useful tool for weight loss, it’s also shown to have many benefits for metabolic health – independent of weight loss. Yet many people may find intermittent fasting to be a challenge, especially if following the 5:2 version of the diet where calories are severely restricted two days a week.

But my latest study shows that you don’t need to severely restrict your calories to get the metabolic benefits of intermittent fasting. Even just restricting the number of carbs you eat twice a week may be enough to improve your metabolic health.

Intermittent fasting appears to be so beneficial for health because of the way it alters our metabolism.

After a meal, our body enters the postprandial state. While in this state, our metabolism pushes our cells to use carbohydrates for immediate energy, while storing some of these carbs as well as fat for later use. But after several hours without food, in the postabsorptive “fasted” state, our metabolism switches to using some of our fat stores for energy.

In this regard, intermittent fasting ensures a better balance between the sources it uses for energy. This leads to improved metabolic flexibility, which is linked with better cardiometabolic health. In other words, this means lower risk of cardiovascular disease, insulin resistance and type 2 diabetes.

My colleagues and I previously ran a study to demonstrate the effects of a fast on the body. We observed that following a day of both total fasting or severe calorie restriction (eating around only 25% of each person’s daily calorie requirements), the body was better at clearing and burning the fat of a full English breakfast the next day. Fasting shifted the body from using carbs to using fat. This effect carried on both during the fast and the next day.

Our research has also compared the effects of intermittent fasting to a calorie-matched or calorie-restricted diet. Both groups followed the diet until they lost 5% of their body weight.

Despite both groups losing the same 5% of body weight, and at the same rate, the intermittent fasting group had greater improvements in their metabolic handling, similar to what we saw in the previous trial.

Other researchers who have compared the effects of the 5:2 variant of the intermittent fasting diet to a calorie-matched, calorie-restricted diet have also found fasting is beneficial for metabolic health.

Metabolic health benefits

But why exactly is intermittent fasting so beneficial for metabolic health? This is a question I sought to answer in my latest study.

For people who follow the 5:2 intermittent fasting diet, typical fasting days are, by their nature, very low in calories – equating to only a few hundred calories per day. Because people are consuming so few calories on fasting days, it also means they’re consuming very few carbohydrates. Given the postprandial state is governed by carbohydrate availability, this begged the question as to whether it’s the calorie restriction or the carbohydrate restriction that’s creating the metabolic effect when intermittent fasting.

We recruited 12 overweight and obese participants. Participants were first given a very low-carb diet one day. Another day, they were given a severely calorie-restricted diet (around 75% fewer calories than they’d normally eat). After each fasting day, we gave them a high-fat, high-sugar meal (similar to an English breakfast) to see how easily their bodies burned fat.

What we found was that the shift to fat burning and improved fat handling of the high-calorie meal were near identical following both the traditional calorie-restricted “fast” day and the low-carb day. In other words, restricting carbs can elicit the same favourable metabolic effects as fasting.

It will be important now for more studies to be conducted using a larger cohort of participants to confirm these findings.

Such findings may help us address some of the practical problems we face with intermittent fasting and traditional low-carb diets.

For intermittent fasting diets, severe calorie restriction on fasting days can increase the risk of nutritional deficiencies if not careful. It can similarly be a trigger for disordered eating.

Strict carb restriction can also be challenging to adhere to long-term, and may lead to an unhealthy fear of carbs.

The other limitation of both intermittent fasting and continuous carb restriction is that weight loss is a likely outcome. Hence these approaches are not universally beneficial for those who need to improve their health without losing weight or those looking to maintain their weight.

We are now testing the feasibility of an intermittent carb restriction diet, or a low-carb 5:2. So instead of restricting calories two days a week, you would restrict the number of carbs you consume twice a week. If this is proven to be beneficial, it would offer the benefits of fasting without restricting calories on “fast” days.

Adam Collins, Associate Professor of Nutrition, University of Surrey

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Categories : HIVTags :

How US Funding Cuts are Forcing Sex Workers to Share HIV Medicines

On By ModernMedia

By Kimberly Mutandiro

Sex workers in Vosloorus, Johannesburg and Springs talked to GroundUp about their struggle to access health services, particularly antiretroviral treatment, since the closures of US funded clinics. Photos: Kimberly Mutandiro

It’s afternoon on Boundary Road in Vosloorus. Sex worker Simangele (not her real name) hopes to secure her next client.

Making enough money to pay rent has always been a concern for Simangele. But now she has a new worry: how to keep up with her antiretroviral treatment.

Two months ago the closure of a mobile clinic — where Simangele and other sex workers in Vosloorus went for checkups and to collect their treatment — left her without access to the life-saving medication.

The mobile clinic was run by the Wits Reproductive Health and HIV Institute (WITS RHI) which heavily relied on US funding. The institute has been providing critical sexual and reproductive health services since 2018. The programme was one of many health facilities forced to halt services at the end of January in the wake of US funding cuts for global aid.

Speaking to GroundUp, Simangele says she ran out of antiretroviral medicines (ARVs) over a month ago and has resorted to borrowing a few tablets from a friend. “I don’t know what I will do because the tablets my friend gets give me side effects,” she says. (Antiretrovirals treat HIV. They have to be taken daily for life.)

She says the clinic closed without any warning or before they could give them transfer letters to public healthcare facilities. She is now dreading having to go to a public facility where she says sex workers are frequently discriminated against, particularly those who are undocumented.

We spoke to a dozen other sex workers in Joburg and in Springs who are worried about defaulting on their antiretroviral treatment following the closure of the Wits RHI clinics. The clinics also provided pre-exposure prophylaxis (PrEP) (to prevent HIV-negative people contracting HIV), and treatments for sexually transmitted infections, TB, sexual reproductive health services, and counselling.

A sex worker shows the last few ARVs she has left.

Another sex worker said, “The minute we go to public clinics, they will need documents, which some of us do not have … Wits made time to listen to our problems as sex workers. Even when we faced challenges with clients, they never judged us.”

Sisi (not her real name), who rents rooms and assists sex workers in Vosloorus, said she’s aware of several sex workers who have defaulted and no longer have access to condoms, lubricants, and treatment for sexually transmitted infections. “The Wits clinic did not discriminate against people without documents and would sometimes provide food, branded T-shirts, caps, and even jobs,” she said.

“Many of us will die”

We visited Zig Zag Road in Springs, where several sex workers said they were out or almost out of ARVs. When asked why they didn’t just go to a local clinic, they told GroundUp about instances where they experienced stigma while trying to access treatment at public clinics.

“I used to receive PrEP to help prevent HIV (from the Wits clinic). We would also receive birth control services. Now I can’t go to a public clinic because we are mocked for being sex workers,” said Siphesihle.

Ntombi, who waits for clients along End Street, attended one of the Wits clinics in Hillbrow which closed down. She said those on PrEP were given transfer letters before the clinic closed.

Other workers nearby told GroundUp that they now pay up to R250 for PrEP, which is more than they can afford.

Sisonke calls for urgent response to crisis

The Sisonke National Movement, which advocates for the rights of sex workers, has been raising the alarm since the closure of US-funded facilities. Before the closures, Sisonke was in talks with National Department of Health through the South African National AIDS Council about the provision of services to sex workers and other vulnerable groups, said the organisation’s spokesperson Yonela Sinqu.

She said that the department never answered activists when they asked what would happen should donor funds no longer be available for these facilities.

She said the plea for assistance without referral letters is made to all provinces, not only Gauteng. However, Gauteng is the only province that has approached us with the crisis of people without referrals, she said.

Department of Health spokesperson Foster Mohale has not responded to requests for comment.

Republished from GroundUp under a Creative Commons Attribution-NoDerivatives 4.0 International License.

Read the original article.

Categories : Cancer Obstetrics & GynaecologyTags :

Removing Ovaries and Fallopian Tubes Linked to Lower Risk of Early Death Among Certain Breast Cancer Patients

On By ModernMedia
Photo by National Cancer Institute on Unsplash

Women diagnosed with breast cancer who carry particular BRCA1 and BRCA2 genetic variants are offered surgery to remove the ovaries and fallopian tubes as this dramatically reduces their risk of ovarian cancer. Now, Cambridge researchers have shown that this procedure – known as bilateral salpingo-oophorectomy (BSO) – is associated with a substantial reduction in the risk of early death among these women, without any serious side-effects.

Women with certain variants of the genes BRCA1 and BRCA2 have a high risk of developing ovarian and breast cancer. These women are recommended to have their ovaries and fallopian tubes removed at a relatively early age – between the ages 35 and 40 years for BRCA1 carriers, and between the ages 40 and 45 for BRCA2 carriers.

Previously, BSO has been shown to lead to an 80% reduction in the risk of developing ovarian cancer among these women, but there is concern that there may be unintended consequences as a result of the body’s main source of oestrogen being removed, which brings on early menopause. This can be especially challenging for BRCA1 and BRCA2 carriers with a history of breast cancer, as they may not typically receive hormone replacement therapy to manage symptoms. The overall impact of BSO in BRCA1 and BRCA2 carriers with a prior history of breast cancer remains uncertain. 

Ordinarily, researchers would assess the benefits and risks associated with BSO through randomised controlled trials, the ‘gold standard’ for testing how well treatments work. However, to do so in women who carry the BRCA1 and BRCA2 variants would be unethical as it would put them at substantially greater risk of developing ovarian cancer.

To work around this problem, a team at the University of Cambridge, in collaboration with the National Disease Registration Service (NDRS) in NHS England, turned to electronic health records and data from NHS genetic testing laboratories collected and curated by NDRS to examine the long-term outcomes of BSO among BRCA1 and BRCA2 PV carriers diagnosed with breast cancer. The results of their study, the first large-scale study of its kind, are published today in The Lancet Oncology.

The team identified a total of 3400 women carrying one of the BRCA1 and BRCA2 cancer-causing variants (around 1700 women for each variant). Around 850 of the BRCA1 carriers and 1,000 of the BRCA2 carriers had undergone BSO surgery.

Women who underwent BSO were around half as likely to die from cancer or any other cause over the follow-up period (a median follow-up time of 5.5 years). This reduction was more pronounced in BRCA2 carriers compared to BRCA1 carriers (a 56% reduction compared to 38% respectively). These women were also at around a 40% lower risk of developing a second cancer.

Although the team say it is impossible to say with 100% certainty that BSO causes this reduction in risk, they argue that the evidence points strongly towards this conclusion.

Importantly, the researchers found no link between BSO and increased risk of other long-term outcomes such as heart disease and stroke, or with depression. This is in contrast to previous studies that found evidence in the general population of an association between BSO and increased risk of these conditions.

First author Hend Hassan, a PhD student at the Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, and Wolfson College, Cambridge, said: “We know that removing the ovaries and fallopian tubes dramatically reduces the risk of ovarian cancer, but there’s been a question mark over the potential unintended consequences that might arise from the sudden onset of menopause that this causes.

“Reassuringly, our research has shown that for women with a personal history of breast cancer, this procedure brings clear benefits in terms of survival and a lower risk of other cancers without the adverse side effects such as heart conditions or depression.”

Most women undergoing BSO were white. Black and Asian women were around half as likely to have BSO compared to white women. Women who lived in less deprived areas were more likely to have BSO compared to those in the most-deprived category.

Hassan added: “Given the clear benefits that this procedure provides for at-risk women, it’s concerning that some groups of women are less likely to undergo it. We need to understand why this is and encourage uptake among these women.”

Professor Antonis Antoniou, from the Department of Public Health and Primary Care, the study’s senior author, said: “Our findings will be crucial for counselling women with cancer linked to one of the BRCA1 and BRCA2 variants, allowing them to make informed decisions about whether or not to opt for this operation.”

Professor Antoniou, who is also Director of the Cancer Data-Driven Detection programme, added: “The study also highlights the power of exceptional NHS datasets in driving impactful, clinically relevant research.”

The research was funded by Cancer Research UK, with additional support from the National Institute for Health and Care Research (NIHR) Cambridge Biomedical Research Centre.

The University of Cambridge is fundraising for a new hospital that will transform how we diagnose and treat cancer. Cambridge Cancer Research Hospital, a partnership with Cambridge University Hospitals NHS Foundation Trust, will treat patients across the East of England, but the research that takes place there promises to change the lives of cancer patients across the UK and beyond. Find out more here.

Reference

Hassan, H et al. Long-term health outcomes of bilateral salpingo-oophorectomy in BRCA1 and BRCA2 pathogenic variant carriers with personal history of breast cancer: a retrospective cohort study using linked electronic health records. Lancet Oncology; 7 May 2025; DOI: 10.1016/S1470-2045(25)00156-1

The original text of this story is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Read the original article.

Categories : Environmental EffectsTags :

Martian Dust Could be a Health Hazard to Future Astronauts

On By ModernMedia
Photo by RDNE Stock project

Don’t breathe in the dust on Mars.

That’s the takeaway from new research from a team of scientists, including researchers from the University of Colorado Boulder. The findings suggests that long-term exposure to Martian dust could create a host of health problems for future astronauts – leading to chronic respiratory problems, thyroid disease and more.

The study, published in the journal GeoHealth, is the first to take a comprehensive look at the chemical ingredients that make up Martian dust, and their possible impacts on human health. It was undertaken by a team from the worlds of medicine, geology and aerospace engineering.

“This isn’t the most dangerous part about going to Mars,” said Justin Wang, lead author of the study and a student in the Keck School of Medicine at the University of Southern California in Los Angeles. “But dust is a solvable problem, and it’s worth putting in the effort to develop Mars-focused technologies for preventing these health problems in the first place.”

Wang, a CU Boulder alumnus, noted that Apollo era astronauts experienced runny eyes and irritated throats after inhaling dust from the moon. Apollo 17’s Harrison Schmitt likened the symptoms to hay fever.

But scientists know a lot less about the potential harms of Martian dust. To begin to answer that question, Wang and his colleagues drew on data from rovers on Mars and even Martian meteorites to better understand what makes up the planet’s dust. The group discovered a “laundry list” of chemical compounds that could be dangerous for people—at least when inhaled in large quantities and over long periods of time.

They include minerals rich in silicates and iron oxides, metals like beryllium and arsenic and a particularly nasty class of compounds called perchlorates.

In many cases, those ingredients are present in only trace amounts in Mars dust. But the first human explorers on Mars may spend around a year and a half on the surface, increasing their exposure, said study co-author Brian Hynek.

“You’re going to get dust on your spacesuits, and you’re going to have to deal with regular dust storms,” said Hynek, a geologist at the Laboratory for Atmospheric and Space Physics (LASP) at CU Boulder. “We really need to characterize this dust so that we know what the hazards are.”

Into the bloodstream

One thing is clear, he added: Mars is a dusty place.

Much of the planet is covered in a thick layer of dust rich in tiny particles of iron, which gives the planet its famous red colour. Swirling dust storms are common and, in some cases, can engulf the entire globe.

“We think there could be 10 metres of dust sitting on top of the bigger volcanoes,” said Hynek, a professor in the Department of Geological Sciences. “If you tried to land a spacecraft there, you’re going to just sink into the dust.”

Wang found his own way to Martian dust through a unique academic path. He started medical school after earning bachelor’s degrees from CU Boulder in astronomy and molecular, cellular and developmental biology, followed by a master’s degree in aerospace engineering sciences. He currently serves in the Navy through its Health Professions Scholarship Program.

He noted that the biggest problem with Martian dust comes down to its size. Estimates suggest that the average size of dust grains on Mars may be as little as 3 micrometers across, or roughly one-ten-thousandth of an inch.

“That’s smaller than what the mucus in our lungs can expel,” Wang said. “So after we inhale Martian dust, a lot of it could remain in our lungs and be absorbed into our blood stream.”

An ounce of prevention

In the current study, Wang and several of his fellow medical students at USC scoured research papers to unearth the potential toxicological effects of the ingredients in Martian dust.

Some of what they found resembled common health problems on Earth. Dust on Mars, for example, contains large amounts of the compound silica, which is abundant in minerals on our own planet. People who inhale a lot of silica, such as glass blowers, can develop a condition known as silicosis. Their lung tissue becomes scarred, making it hard to breath—symptoms similar to the “black lung” disease that coal miners often contract. Currently, there is no cure for silicosis.

In other cases, the potential health consequences are much less well-known.

Martian dust carries large quantities of highly oxidising compounds called perchlorates, which are made up of one chlorine and multiple oxygen atoms. Perchlorates are rare on Earth, but some evidence suggests that they can interfere with human thyroid function, leading to severe anaemia. Even inhaling a few milligrams of perchlorates in Martian dust could be dangerous for astronauts.

Wang noted that the best time to prepare for the health risks of Martian dust is before humans ever make it to the planet. Iodine supplements, for example, would boost astronauts’ thyroid function, potentially counteracting the toll of perchlorates – although taking too much iodine can also, paradoxically, lead to thyroid disease. Filters specifically designed to screen out Martian dust could also help to keep the air in living spaces clean.

“Prevention is key. We tell everyone to go see their primary care provider to check your cholesterol before it gives you a heart attack,” Wang said. “The best thing we can do on Mars is make sure the astronauts aren’t exposed to dust in the first place.”

Source: University of Colorado at Boulder