Category: Environmental Effects

Categories : Environmental EffectsTags :

WHO Tightens Air Quality Guidelines

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New WHO Global Air Quality Guidelines (AQGs) have lowered the acceptable limits of air pollution, providing evidence that even lower concentrations than previously understood have a negative health impact.

Increasing evidence showing how air pollution affects different aspects of health, WHO has adjusted almost all the AQGs levels downwards, warning that exceeding the new air quality guideline levels is associated with significant risks to health.

Air pollution is estimated to cause 7 million premature deaths and the loss of millions more healthy years of life. In children, this could include reduced lung growth and function, respiratory infections and aggravated asthma. In adults, deaths from ischaemic heart disease and stroke are the most common, as well as emerging evidence of diabetes and neurodegenerative conditions. This makes the disease burden from air pollution on par with others such as unhealthy diet and tobacco smoking.

Besides climate change, air pollution is one of the biggest environmental threats to human health. Improving air quality will also help mitigate climate change, thereby reducing the negative health impacts of both.
WHO’s new guidelines recommend air quality levels for 6 pollutants, where evidence has advanced the most on health effects from exposure. When action is taken on these so-called classical pollutants – particulate matter (PM), ozone (O₃), nitrogen dioxide (NO₂) sulfur dioxide (SO₂) and carbon monoxide (CO), it also has an impact on other damaging pollutants.

Particulate matter equal or smaller than 10 and 2.5 microns (µm) in diameter (PM₁₀ and PM₂.₅, respectively) is a particular health concern. Both PM₂.₅ and PM₁₀ can penetrate deep into the lungs but PM₂.₅ can even enter the bloodstream, primarily resulting in cardiovascular and respiratory impacts, and also affecting other organs, and were classified as carcinogenic in 2013.

“Air pollution is a threat to health in all countries, but it hits people in low- and middle-income countries the hardest,” said WHO Director-General, Dr Tedros Adhanom Ghebreyesus. “WHO’s new Air Quality Guidelines are an evidence-based and practical tool for improving the quality of the air on which all life depends. I urge all countries and all those fighting to protect our environment to put them to use to reduce suffering and save lives.”

In 2019, over 90% of the world’s population lived in areas where concentrations exceeded the 2005 WHO air quality guideline for long term exposure to PM₂.₅.

Almost 80% of PM₂.₅-related deaths could be avoided if current air pollution levels were reduced to those proposed in the updated guideline. At the same time, reaching interim targets would reduce the burden of disease, of which the greatest benefit would be observed in countries with high concentrations of fine particulates (PM₂.₅) and large populations.

Source: World Health Organization

Categories : Environmental Effects ExerciseTags :

‘Uncomfortable’ Urban Spaces Result in Slower, Uncertain Walking

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Stepping patterns become slower and more variable when a person is not comfortable with their environment, researchers have found.

The findings, published in PLoS One, shows that the perceived comfort of an environment, rather than it being natural or not, affects how people walk, with potential lessons for urban design.

Lead author Daria Burtan of Bristol’s School of Psychological Science said: “Measuring the changes of a person’s walking patterns through an environment allows us to understand their experienced comfort on a moment-to-moment basis.

“This is an important step toward being able to objectively quantify the impact of particular architectural designs on people’s wellbeing.”

Research has shown that spending time in green spaces such as parks helps improve attention spans, concentration and wellbeing, which can be shown by improvements in measured stepping patterns when walking in different environments.

Daria added: “As our cognitive faculties begin to decline in older age, the stepping patterns we make with our feet become slower and more variable, relative to when we are younger in the prime of our health. We found that the same thing happened when people walked toward images of urban and nature scenes they didn’t feel comfortable with – their stepping patterns became slower and more varied, relative to when they were looking at scenes they found comfortable and which they liked.

“Not only does this suggest that environments in which we feel comfortable and safe, place fewer processing demands on our brains; it demonstrates how measuring the real-time dynamics of our gait provides us with a powerful new tool for informing on the cognitive impacts of architecture and urban design.”

The researchers are now seeking to understand which psychological factors contribute to sensory discomfort.

Source: University of Bristol

Categories : Environmental EffectsTags :

Low-level Air Pollution Still Linked to Higher Mortality

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Long-term exposure to air pollution appears to still be linked to higher mortality despite the existence of air quality standards that restrict levels of pollution, suggests a study published online in The BMJ today.

Previous studies have found an association between long term exposure to outdoor air pollution such as those in the form of fine particles in the air (known as particulate matter or PM2.5) and nitrogen dioxide (NO2) and illness or mortality.

While air pollution concentrations have fallen substantially in Europe since the 1990s, it is unclear whether there still is a link between pollution and ill health or death at pollution levels under permitted levels.

Therefore, researchers set out to determine if there was an association between low levels of air pollution concentrations and natural and cause-specific deaths.

Low-level air pollution was defined as concentrations below current limits set by the European Union, US Environmental Protection Agency and the World Health Organization (WHO).

The researchers analysed data on eight groups of people within six European countries. Their study recruited participants in the 1990s or 2000s. Of the 325 367 participants who were followed up over an almost 20-year period, around 14.5% (47 131 people) died during the study period.

An increase of 5 µg/m3 (a concentration measure of particulate matter) in particulate matter (PM2.5) was associated with a 13% increase in natural deaths while the corresponding figure for a 10 µg/m3 increase in nitrogen dioxide was 8.6%. Associations with PM2.5 and NO2 were largely independent of each other.

Moreover, even at low to very low concentrations, associations with PM2.5, NO2, and black carbon remained significant. For people exposed to pollution levels below the US standard of 12 µg/m3, an increase of 5 µg/m3 in PM2.5 was associated with a 29.6% increase in natural deaths. People exposed to NO2at less than half the current EU standard of 40 µg/m3, a 10 µg/m3 increase in NO2 was associated with a 9.9% increase in natural deaths.

The study also has some limitations, the researchers said, such as the fact that it focused on exposure in 2010 which was towards the end of the follow-up period for most participants and, given falling air pollution, this measure might not exactly reflect the concentrations experienced during follow-up.

However, this was a large study from multiple European groups of people with detailed information provided. As such, the authors concluded: “Our study contributes to the evidence that outdoor air pollution is associated with mortality even at levels below the current European and North American standards and WHO guideline values.

“These findings are therefore an important contribution to the debate about revision of air quality limits, guidelines and standards, and future assessments by the Global Burden of Disease [study].”

Source: The BMJ

Categories : Environmental EffectsTags :

Obesity Connection to Commonly-used Pesticide

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A commonly-used pesticide could be contributing to the global obesity epidemic, according to a new study.

Researchers discovered that chlorpyrifos slows down the burning of calories in the brown adipose tissue of mice. Reducing this burning of calories, a process known as diet-induced thermogenesis, causes the body to store these extra calories, promoting obesity. Chlorpyrifos is banned for use on foods in Canada, and also now banned in the US and, as of last year, the EU, but widely sprayed on fruits and vegetables in many other parts of the world. In South Africa it is banned for residential use but is still used in agriculture.

Scientists made the discovery after studying 34 commonly used pesticides and herbicides in brown fat cells and testing the effects of chlorpyrifos in mice fed high calorie diets. Their findings were published in Nature Communications and could have important implications for public health.

“Brown fat is the metabolic furnace in our body, burning calories, unlike normal fat that is used to store them. This generates heat and prevents calories from being deposited on our bodies as normal white fat. We know brown fat is activated during cold and when we eat,” said senior author Gregory Steinberg, professor of medicine and co-director of the Centre for Metabolism, Obesity, and Diabetes Research at McMaster.

“Lifestyle changes around diet and exercise rarely lead to sustained weight loss. We think part of the problem may be this intrinsic dialling back of the metabolic furnace by chlorpyrifos.”

Steinberg said chlorpyrifos would only need to inhibit energy use in brown fat by 40 calories every day to trigger obesity in adults, which would translate to an extra 2kg of weight gain per year.

He said that while several environmental toxins including chlorpyrifos have been associated with increasing obesity rates in both humans and animals, these studies have mostly attributed weight gain to increases in food intake and not calorie burning.

“Although the findings have yet to be confirmed in humans, an important consideration, is that whenever possible consume fruits and vegetables from local Canadian sources and if consuming imported produce, make sure it is thoroughly washed,” said Steinberg.

Source: Medical Xpress

Categories : Environmental Effects Mental HealthTags :

Heat Waves Increase Aggression in Mental Health Wards

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According to a new study from Germany, heatwaves may increase aggressive patient behaviour in mental health wards.

Studies have shown an association between increased temperature and the incidence of violent crimes, accounting for about 10% of the variance in one study in Finland. This effect has also been seen within the context of American Football games, with more penalties for aggressive behaviour given for visiting teams on hotter days.

Researchers from ZfP Südwürttemberg and Ulm University in Germany drew on local weather data and incident reporting data to examine the impact of hot weather on mental health inpatient wards.

They discovered that there were an average of 15% more aggressive incidents on days over 30°C (9.7 per day) compared to days under 30°C (8.4 per day).

A clear relationship was also seen between the temperature of hot days (those over 30°C) and the number of aggressive incidents. As the temperature increased, the higher the rate of incidents, which reached a peak of 11.1 on the very hottest days (over 33.5°C).

The findings suggest that temperature is the cause of the increase in incidents, rather than another factor. No equivalent correlation was found between temperature on hot days and the use of restrictive practices by hospital staff.

Staff recorded aggressive incidents according to a standardised protocol, documenting the nature of the aggression (eg physical, verbal), the target (eg staff, patients), the impact and any subsequent measures taken.

The data for the study came from six German mental health hospitals and covered 13 years (2007-2019), 1007 beds and 164 435 admissions. Over this period, there were a total of 207 days over 30°C. All six hospitals were built according to modern building standards, but all lacked air-conditioning.

Lead author Dr Hans Knoblauch said: “The climate emergency means that many areas of the world could experience significantly more hot weather in the future.

“While more research into the mental health consequences is needed, these findings could have practical implications for mental healthcare, particularly around hospital design and architecture.”

His colleague, Professor Tilman Steinert, from Ulm University, commented: “These findings highlight an underappreciated impact of the climate emergency on mental health services. Increased aggression is an indicator of increased distress and an environment that is failing to help patients recover.

“Urgent action is now needed, to replicate the findings of this study using more measurements within mental health hospitals, to invest in those hospitals, and to tackle the climate crisis. Mental health patients deserve better.”

Source: EurekaAlert!

Journal information: Frank Eisele et al, Aggressive incidents in psychiatric hospitals on heat days, BJPsych Open (2021). DOI: 10.1192/bjo.2021.33

Categories : Environmental EffectsTags :

Global Warming Drives a Third of Heat-related Deaths

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While the COVID pandemic will eventually die down, the health threat from global warming will only increase as long as countries fail to control their emissions. Between 1991 and 2018, more over of all deaths in which heat played a role were attributable to human-induced global warming, according to a groundbreaking new study.

Global warming is impacting human health in a number of ways, from direct effects linked to wildfires and extreme weather, to changes in the spread of vector-borne diseases. One of the most striking ways is in the increase in heat-associated mortality and morbidity. Climate projections predict a rise in average global temperature, with extreme events such as heatwaves adding to future health burden. However, until now no research has been conducted into what extent these impacts have already occurred in recent decades until now. Research to answer these questions was led by the London School of Hygiene & Tropical Medicine (LSHTM) and the University of Bern within the Multi-Country Multi-City (MCC) Collaborative Research Network. 

This new study focused on man-made global warming through a ‘detection & attribution’ study that identifies and attributes observed phenomena to weather and climate changes. Specifically, the team examined past weather conditions simulated under scenarios with and without anthropogenic emissions. This enabled the researchers to separate the warming and related health impact linked with human activities from natural trends. Heat-related mortality was defined as the number of deaths attributed to heat, occurring at exposures higher than the optimum temperature for human health, which varies across locations.

Published in Nature Climate Change, the study used data from 732 locations in 43 countries around the world. For the first time, it shows the actual contribution of man-made climate change in increasing mortality risks due to heat.

The study estimates that 37% of all heat-related deaths in the recent summer periods were attributable to the warming of the planet due to human activities. These deaths were highest in hot regions such as Central and South America (up to 76% in Ecuador or Colombia, for example) and South-East Asia (between 48% to 61%).

Estimates also showed the number of deaths from human-induced climate change that occurred in specific cities; 136 additional deaths per year in Santiago de Chile (44.3% of total heat-related deaths in the city), 189 in Athens (26.1%), 172 in Rome (32%), 156 in Tokyo (35.6%), 177 in Madrid (31.9%), 146 in Bangkok (53.4%), 82 in London (33.6%), 141 in New York (44.2%), and 137 in Ho Chi Minh City (48.5%).

The authors said their findings bolster evidence in favour of adopting strong mitigation policies to reduce future warming, and to implement interventions to protect populations from the adverse consequences of heat exposure.

First author Dr Ana M Vicedo-Cabrera, from the University of Bern, said: “We expect the proportion of heat-related deaths to continue to grow if we don’t do something about climate change or adapt. So far, the average global temperature has only increased by about 1°C, which is a fraction of what we could face if emissions continue to grow unchecked.”

While on average over a third of heat-related deaths are due to human-induced climate change, there is considerable regional variation. Climate-related heat casualties range from a few dozen to several hundred deaths each year per city, as shown above, depending on the local changes in climate in each area and the vulnerability of its population. Populations living in low and middle-income countries are those most affected yet produce the least global warming emissions.

Senior author Professor Antonio Gasparrini from LSHTM, and coordinator of the MCC Network, said: “This is the largest detection & attribution study on current health risks of climate change. The message is clear: climate change will not just have devastating impacts in the future, but every continent is already experiencing the dire consequences of human activities on our planet. We must act now.”

The authors acknowledge limitations of the study include a lack of empirical data from certain regions such as Africa.

Source: London School of Hygiene and Tropical Medicine

Journal information: Vicedo-Cabrera, A.M., et al. (2021) The burden of heat-related mortality attributable to recent human-induced climate change. Nature Climate Change. doi.org/10.1038/s41558-021-01058-x.

Categories : Environmental Effects Lab Tests and ImagingTags :

Lab Finds Benzene in Many Sunscreen Products

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Some sunscreen products have been found to contain benzene, a known carcinogen. Photo by RF._.studio from Pexels

An online pharmacy company that also conducts independent testing of consumer products has detected benzene in several sunscreen products.

The company, Valisure LLC, has issued a petition to the Food and Drug Administration in the US to enact stricter rules regarding the presence of benzene in sunscreen products. 

Benzene is a colourless or light-yellow liquid chemical at room temperature. A widely used chemical, it has been used primarily as a solvent in the chemical and pharmaceutical industries and is a known carcinogen. Trace levels of benzene may be found in cigarette smoke, gasoline, glues, cleaning products, and paint strippers.

The FDA has forbidden the intentional introduction of the chemical into commercial products due to its toxic properties. The agency does, however, allow benzene-containing products to be sold if the product provides a “substantial therapeutic advance”, on the condition that levels in the product are at or below 2% and that the introduction of benzene into the product is unavoidable. Currently the agency has no guidelines regarding benzene levels in sunscreen products.

Over the past several years, Valisure has become a respected name in product testing—they were behind efforts to have the carcinogen NDMA removed from heartburn medications in 2018, and more recently led the effort to recall hand sanitizers that contained benzene. In 2020, they detected NDMA in metformin, leading to widespread product recalls.
In this new effort, the company tested 294 unique batches from 69 different companies. They found significant variability from batch to batch, even within a single company. Fourteen lots of sunscreen and after-sun care products from four different brands contained between 2.78 – 6.26 ppm of benzene; 26 lots from eight brands contained detectable benzene between 0.11 – 1.99 ppm; and 38 lots from 17 brands contained detectable benzene at < 0.1 ppm. 
There was no detection of benzene in an additional 217 batches of sunscreen from 66 different brands through initial analysis of at least one sample. 
The company also noted that some of the products they tested had levels that were higher than the 2% cap mandated by the FDA. They also noted that since most of the products they tested did not have any detectable amounts of benzene, it clearly is not an unavoidable byproduct of production. The FDA recently discovered that sunscreen chemicals can be readily absorbed through the skin, they added.

Their petition asks the FDA to ban any amount of benzene in sunscreen and after-tanning care products and issue a recall for those that have measurable levels of benzene that have already been sold. They have also published a table [PDF] that lists sunscreens brands with no detectable levels of benzene in them.

Source: Medical Xpress

Categories : Environmental EffectsTags :

How Air Pollution Causes Loss of Smell

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Johns Hopkins Medicine researchers have studied how long-term exposure to air pollution causes loss of smell, or anosmia, to better understand how it can rob someone of the ability to smell and taste.

Anosmia can severely impact a person’s quality of life, making it extremely difficult to taste foods, detect airborne hazards in the environment, and other functions. People with anosmia may experience weight concerns, decreased social interaction, depression and general anxiety. Loss of smell has been linked in some cases to death in older adults. 

“We included participants from a variety of areas in our study; however, most lived in urban areas where pollution levels are highest,” says lead author Murugappan “Murray” Ramanathan, MD, rhinologist and associate professor of otolaryngology–head and neck surgery at the Johns Hopkins University School of Medicine. “We wanted to assess how their exposure to PM2.5 air pollution—inhalable, particulate matter less than 2.5 micrometers in size or about 30 times smaller than the diameter of a human hair—might cause them to lose their sense of smell.”

According to the US Environmental Protection Agency (EPA), PM2.5 (the PM stands for ‘particulate matter’) is the term for a mixture of solid particles and liquid droplets found in the air, and are smaller even than pollen grains. PM2.5 can be made of many materials depending on the location, such as dust, dirt, soot, smoke, organic compounds and metals. These particulated have been linked to cardiovascular disease, lung cancer, cognitive decline, chronic obstructive pulmonary disease, asthma and premature death. Previous studies have suggested PM2.5 is a likely culprit in loss of smell—a connection that Prof Ramanathan and his team decided to explore in greater detail.

In their study, the researchers examined data for 2690 people, aged 18 years and older, who were evaluated by otolaryngologists between January 2013 and December 2016. Of these, 538 were diagnosed with anosmia, with an average age of 54, the majority being men (63%).

The EPA’s Air Quality System provided air pollution data for the study. The researchers entered the data into a detailed computer simulation to estimate the PM2.5 pollution levels within the participants’ residential ZIP codes. The model was created by Zhenyu Zhang, a Johns Hopkins Medicine otolaryngology postdoctoral fellow.

The researchers found that long-term airborne exposure to PM2.5 nearly doubles (a 1.6- to 1.7-fold increase) the risk of losing one’s ability to smell. They believe this may occur due to the location of the olfactory nerve—which contains the sensory nerve fibres associated with the sense of smell—being directly in the path of inhaled PM2.5 materials.

“Based on this result, we feel that long-term exposure to high levels of PM2.5 represents a common risk factor for the loss of sense of smell, especially in vulnerable populations such as older people—but also one that is potentially modifiable if sources of PM2.5 components can be better controlled,” says Ramanathan.

The researchers next steps are to study anosmia patients’ socioeconomic factors to find out if they affect the chances of exposure to PM2.5 air pollution. They also hope to evaluate other air pollution components that may contribute to loss of smell, such as ozone.

Source: Medical Xpress

Journal information: Zhenyu Zhang et al, Exposure to Particulate Matter Air Pollution and Anosmia, JAMA Network Open (2021). DOI: 10.1001/jamanetworkopen.2021.11606

Categories : Environmental EffectsTags :

Study Finds High Levels of ‘Forever Chemicals’ in Firefighters’ Bodies

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A new study has shown that volunteer firefighters have higher levels of ‘forever chemicals‘, per- and polyfluoroalkyl substances (PFAS), in their bodies than the general population.

Volunteer firefighters—who comprise more than 65 percent of the U.S. fire service—monitored their exposure to PFAS. PFAS are synthetic organic substances with diverse structures, properties, uses, bioaccumulation potentials and toxicities. These chemicals do not break down easily and accumulate in human bodies and in the environment and are found in common items food packaging, electronics and carpeting. PFAS have been associated with a number health conditions that affect firefighters, including cardiovascular disease, and increasingly to cancer.

“The primary cause of line-of duty death among firefighters are heart attacks. They also get and die from many types of cancer more often than other people,” said lead author Judith Graber, an associate professor at Rutgers School of Public Health and a faculty member at the Environmental and Occupational Health Sciences Institute. “More than 95 percent of the U.S. population have these chemicals to some degree in their bodies, but firefighters have heightened exposure to PFAS through their protective gear and fire suppression foam and the burning materials they encounter that release particles, which can be inhaled or settle on gear and skin.”

The study surveyed 135 members of a volunteer fire department in New Jersey on their lifestyle and cancer risk factors. It compared traces of nine PFAS chemicals in their blood against the levels recorded in a 5000-strong nationally representative sample used by the CDC as a reference for the general population. Although over 4000 PFAS chemicals exist, the study looked at the nine chemicals commonly seen in the general population that the CDC has also tracked for the greatest length of time.

Two of thosee chemicals—perfluorododecanoic acid (PFDoA) and perfluorodecanoic acid (PFDA)—were found to be higher in volunteer firefighters. “Notably, we found PFDoA levels in 80 percent of the firefighters, but little in the general public,” Prof Graber said.

The number of years of firefighting was linked to higher levels of the chemicals; the average participant had 20 years of experience. Since they are constantly on call, volunteer firefighters may potentially have more years of firefighting-related exposures than their career counterparts, Graber said.

“The number one risk of a firefighter is being protected from the fire. The chemicals used in fire suppression foam and the protective clothing firefighters use came out 40 years ago when people thought they were safe, and they work well for what they are intended to do,” Prof Graber explained. “Further research is needed to better understand the sources of these chemicals and to design effective foam and protective clothing that do not use these chemicals.”

Source: Medical Xpress

Journal information: Judith M. Graber et al, Prevalence and Predictors of Per- and Polyfluoroalkyl Substances (PFAS) Serum Levels among Members of a Suburban US Volunteer Fire Department, International Journal of Environmental Research and Public Health (2021). DOI: 10.3390/ijerph18073730

Categories : Cancer Environmental EffectsTags :

Low-dose Radiation May be Beneficial to Humans

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A study has found that cancer rates go down and life expectancy increases in areas of the US with high natural background radiation, flying in the face of decades of accepted theory that low-dose radiation is still harmful.

Natural background radiation exists from sources in the environment. This is the first large-scale study looking at terrestrial radiation (coming from radioactive elements in rocks, which vary across regions) and cosmic radiation (which increases with altitude). The Ben-Gurion University of the Negev (BGU) researchers found that life expectancy is approximately 2.5 years longer for those who live in areas of naturally high background radiation vs those who live in areas of low radiation.

The linear no-threshold (LNT) hypothesis has guided radiation protection policy in the US since the 1960s. This assumes that health risk from radiation is linear and incremental, meaning that there is no safe minimum dose – all ionising radiation is assumed to be harmful. However, numerous studies have contended that radiation at low doses initiates a protective hormesis effect.

Reduced levels of a number of types of cancers were found when in areas of high background radiation levels as opposed to lower. In both sexes, there was a significant decrease in lung, pancreatic, colon and rectal cancers. Among men, there were additional decreases in brain and bladder cancers. However, no decreases in cervix, breast or prostate cancers or leukaemia were observed.

“Decades of scientific theory are potentially being disproven by the remarkable researchers at BGU. These findings might even provide a sense of relief for those who reside in areas in the U.S. with higher-than-average background radiation,” said Doug Seserman, Chief Executive Officer, American Associates, BGU.

Using the United States Environmental Protection Agency’s radiation dose calculator, the researchers retrieved data background radiation on all 3,29 US counties. Cancer rate data were retrieved from the United States Cancer Statistics, while life expectancy data were retrieved from the Institute for Health Metrics and Evaluation at the University of Washington Medical Center.

“It is reasonable to suggest that a radiation threshold does exist, yet it is higher than the upper limit of the natural background radiation levels in the US (227 mrem/year),” the researchers wrote. “These findings provide clear indications for re-considering the linear no-threshold paradigm, at least within the natural range of low-dose radiation.”

Source: News-Medical.Net

Journal information: David, E., et al. (2021) Background radiation impacts human longevity and cancer mortality: reconsidering the linear no-threshold paradigm. Biogerontology. doi.org/10.1007/s10522-020-09909-4.